Expression and prognostic value of amphiregulin and interleukin-10 in cervical cancer
10.12354/j.issn.1000-8179.2024.20240933
- VernacularTitle:双调蛋白和白细胞介素10在宫颈癌中的表达及其预后价值
- Author:
Wu YUFENG
1
;
Wang BIHUI
1
;
Chen ZHIFANG
1
Author Information
1. 新疆医科大学第一附属医院妇科中心,省部共建中亚高发病成因与防治国家重点实验室(乌鲁木齐市 830011)
- Publication Type:Journal Article
- Keywords:
cervical cancer(CC);
amphiregulin(AREG);
interleukin-10(IL-10);
prognosis
- From:
Chinese Journal of Clinical Oncology
2024;51(23):1206-1211
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the expression of amphiregulin(AREG)and interleukin-10(IL-10)in tissues and peripheral blood from pa-tients with cervical cancer(CC)and to explore their relationship with patient prognosis.Methods:Cervical cancer tissues of 40 cervical can-cer patients admitted to The First Affiliated Hospital of Xinjiang Medical University from Jan 2017 to Dec 2018 were collected as the cervical cancer group,and the cervical tissues of 30 patients with negative screening results of uterine fibroids were selected as the control group.Immunohistochemistry(IHC)was performed to compare AREG and IL-10 expression between the two groups.Serum samples from 100 patients with CC(cervical cancer group)and 60 normal healthy individuals(control group)admitted during the same period were ana-lyzed for AREG and IL-10 expression using enzyme-linked immunosorbent assay(ELISA).Pearson correlation analysis was used to evaluate the relationship between AREG and IL-10.The 100 patients with cervical cancer were assigned into survivor(80 patients)and deceased(20 patients)groups.A Kaplan-Meier plot was used to analyze the relationship between AREG and IL-10 expression and the survival rates among patients with CC.Binary Logistic regression and receiver operating characteristic curve(ROC)analyses were performed to evaluate prognostic factors.Results:IHC results indicated that AREG and IL-10 were highly expressed in CC tissues compared to normal tissues(P<0.05).ELISA results revealed significantly elevated serum levels of AREG and IL-10 in cancer patients(P<0.000 1).Pearson correlation ana-lysis showed that AREG correlated positively with IL-10(P<0.05,r=0.593 6).Binary Logistic regression analysis identified AREG,IL-10,and lymph node metastasis as independent risk factors impacting survival of patients with CC(all P<0.05).ROC curve analysis showed AREG and IL-10 had high predictive value for survival(AUC=0.897 and 0.874,respectively).Conclusions:Increased AREG and IL-10 expression in tissues and serum of patients with CC suggest that AREG and IL-10 are closely related with the occurrence and progression of the disease.These biomarkers hold significant clinical value for predicting the prognosis of patients with CC.
