18F-FDG PET/CT diagnosis of retropertoneal lymph node metastases in renal cell carcinoma
10.13929/j.issn.1003-3289.2024.12.017
- VernacularTitle:18F-FDG PET/CT诊断肾细胞癌腹膜后淋巴结转移
- Author:
Anhui ZHU
1
;
Fan ZHANG
;
Weifang ZHANG
Author Information
1. 北京大学第三医院核医学科,北京 100191
- Publication Type:Journal Article
- Keywords:
kidney neoplasms;
neoplasm metastasis;
positron-emission tomography and computed tomography
- From:
Chinese Journal of Medical Imaging Technology
2024;40(12):1884-1888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of 18F-FDG PET/CT for diagnosing retropertoneal lymph node metastases in renal cell carcinoma(RCC).Methods Totally 50 RCC patients were enrolled and divided into metastases group(n=16)and non-metastasis group(n=34)according to postoperative pathology showed lymph node metastases or not.PET/CT imaging features were compared between groups,and the diagnostic efficacy of PET/CT at case level and lymph node region level were analyzed compared with pathological findings.Results The maximum diameter of the primary tumor,the short diameter and the maximal standard uptake value of lymph node in metastases group were all larger than those in non-metastasis group(all P＜0.05).PET/CT correctly diagnosed 15 cases in metastases group and 28 cases in non-metastasis group.Among 59 resected retroperitoneal lymph node regions in 50 cases,PET/CT correctly diagnosed metastases in 18 regions.Among other 40 lymph node regions pathology found no metastasis,PET/CT correctly diagnosed 33 regions.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of PET/CT for diagnosing retroperitoneal lymph node metastasis at case level was 93.75％,82.35％,86.0％,71.43％,and 96.55％,respectively,while at lymph node region level was 97.74％,82.50％,86.44％,72.00％and 97.06％,respectively.The short diameter of lymph node was an independent impact factor for diagnosing lymph node metastasis of RCC(OR=487.100,P=0.002).Taken 1.25 cm as the cut-off value,the sensitivity,specificity and the area under the curve of the short diameter of lymph node for diagnosing RCC lymph node metastasis was 93.80％,85.30％and 0.951,respectively.Conclusion 18 F-FDG PET/CT had high sensitivity and negative predictive value for diagnosing RCC retroperitoneal lymph node metastasis.
