A single-center study on the effect of high adsorption hemoperfusion therapy on the efficacy of hypertriglyceridemic acute pancreatitis
10.3969/j.issn.1008-9691.2024.05.009
- VernacularTitle:高吸附血液灌流治疗对高三酰甘油血症性急性胰腺炎疗效影响的单中心研究
- Author:
Xing WANG
1
;
Houqing LU
1
;
Jun WANG
1
Author Information
1. 铜陵市人民医院重症医学科,安徽铜陵 241000
- Publication Type:Journal Article
- Keywords:
Hyperlipidemic acute pancreatitis;
Blood purification;
Hemoperfusion
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2024;31(5):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effect of high adsorption hemoperfusion on hypertriglyceridemic acute pancreatitis (HLAP). Methods A retrospective study was conducted. HLAP patients who received high adsorption hemoperfusion treatment in the Department of Critical Care Medicine,Tongling People's Hospital from May 1,2020 to July 31,2023 were selected as the research objects. The patients were divided into the HA380 high adsorption hemoperfusion group and the HA330 ordinary adsorption hemoperfusion group according to different hemoperfusion devices used. The changes in vital signs before and after treatment with the HA380 high adsorption hemoperfusion device were observed,and the differences in triglyceride (TG) and blood amylase levels before and after hemoperfusion were compared between the HA380 high adsorption hemoperfusion group and the HA330 ordinary adsorption hemoperfusion group. Results A total of 26 patients were included,with 16 cases in the HA380 high adsorption hemoperfusion group and 10 cases in the HA330 ordinary hemoperfusion group. With the increase in the number of hemoperfusion sessions,the heart rate,body temperature,and respiratory rate of the patients in the HA380 high adsorption hemoperfusion group gradually decreased[heart rate (bpm):105.38±21.44,95.31±17.56 vs. 119.93±21.06,body temperature (℃):37.31±0.88,37.22±0.69 vs. 37.99±1.17,respiratory rate (times/min):19.44±5.12,17.00±4.83 vs. 21.94±5.12,all P<0.05],and the systolic blood pressure gradually increased[mmHg (1 mmHg≈ 0.133 kPa):106.81±11.04,120.13±9.14 vs. 97.44±8.23,both P<0.05]. The TG and blood amylase levels in both the HA380 high adsorption hemoperfusion group and the HA330 ordinary adsorption hemoperfusion group gradually decreased after hemoperfusion,reaching the lowest level after the second hemoperfusion,and the TG and blood amylase levels in the HA380 high adsorption hemoperfusion group were significantly lower than those in the HA330 ordinary adsorption hemoperfusion group[TG (mmol/L):9.63±2.57 vs. 15.52±4.07,blood amylase (U/L):759.63±153.29 vs. 973.90±125.94,both P<0.05]. Conclusion The use of hemofiltration combined with high adsorption hemoperfusion in HLAP can rapidly relieve symptoms,reduce blood lipid levels,and alleviate the severity of pancreatitis.
