Discussion on the Mechanism of Ferroptosis in Diabetic Kidney Disease Based on the Theory of"Internal Heat Induced Disease"
10.19879/j.cnki.1005-5304.202401266
- VernacularTitle:基于"内热致癥"探讨铁死亡在糖尿病肾脏病中的作用机制
- Author:
Huixi CHEN
1
;
Yaoxian WANG
;
Huijuan ZHENG
;
Weijing LIU
;
Chenhui XIA
;
Jiale ZHANG
;
Jie LYU
;
Weiwei SUN
Author Information
1. 北京中医药大学东直门医院,北京 100700;北京中医药大学肾病研究所,北京 100700;北京中医药大学,北京 100029
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
internal heat induced diseases;
ferroptosis;
inflammation;
fibrosis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(3):24-28
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is one of the serious complications of diabetes.Ferroptosis causes pathological damage and is involved in the progression of DKD.How to inhibit ferroptosis and delay DKD is a new academic hotspot.The author's team further enriched and proposed the core pathogenesis theory of"internal heat induced disease"on the basis of the traditional DKD"yin deficiency and dryness-heat"theory,and explained the general development law of DKD.In this article,"internal heat"and"Zhengjia"in the theory of DKD"internal heat induced diseases"are used as the starting point to explore the relationship of the main pathological damage of ferroptosis such as activating inflammatory response,enhancing oxidative stress,promoting fibrosis and so on with the internal mechanism of the theory of"internal heat induced diseases",further explained the scientific connotation of DKD"internal heat induced diseases",in order to provide ideas and theoretical basis for the TCM prevention and treatment of DKD.
