Exploration on the Correlation Between Pathogenesis of Spleen Deficiency in Cancer and Reprogramming of Energy Metabolism
10.19879/j.cnki.1005-5304.202401147
- VernacularTitle:肿瘤脾虚病机与能量代谢重编程相关性探讨
- Author:
Ling CHEN
1
;
Jinzu YANG
;
Xin LI
;
Yanlin LU
;
Li TAO
;
Zhiming LI
Author Information
1. 上海中医药大学附属岳阳中西医结合医院,上海 200437
- Publication Type:Journal Article
- Keywords:
spleen deficiency;
tumor;
energy metabolism reprogramming;
mitochondria
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(3):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Energy metabolism reprogramming is one of the pathological mechanisms involved in the occurrence and development of tumors.This article focused on the theory of spleen deficiency in TCM and energy metabolism reprogramming to elaborate the pathological mechanism of tumors.TCM believes that spleen deficiency is an important organ pathogenesis that causes cancer due to deficiency,and spleen deficiency runs through the occurrence and development of tumors.The spleen is the source of qi and blood transformation and dominates the energy metabolism of the whole body.Mitochondria are the regulatory center of energy metabolism in the body,and abnormal mitochondrial energy metabolism is the manifestation of spleen deficiency at the cellular micro level,which is mainly manifested as the limitation of mitochondrial oxidative phosphorylation and the conversion to aerobic glycolysis to provide energy for the rapid growth of tumors.Therefore,based on the theory of spleen deficiency,the treatment based on spleen strengthening is used to prevent and treat tumors by improving energy metabolism,which not only enriches the modern medical connotation of spleen deficiency in TCM,but also provides a new perspective for TCM to treat malignant tumors from the perspective of spleen strengthening.
