Research Progress of Active Components of Chinese Materia Medica Intervening Ferroptosis for the Treatment of Diabetic Nephropathy
- VernacularTitle:中药活性成分干预铁死亡治疗糖尿病肾病研究进展
- Author:
Xinyu CHEN
1
;
Xinyu MENG
1
;
Yiting HE
1
;
Weiwei CAI
1
;
Bao HOU
1
;
Liying QIU
1
;
Haijian SUN
1
;
Xuexue ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: TCM; diabetic nephropathy; ferroptosis; mechanism; renal protection; review
- From: Chinese Journal of Information on Traditional Chinese Medicine 2025;32(3):192-196,后插1
- CountryChina
- Language:Chinese
- Abstract: Ferroptosis is a form of programmed cell death,which plays a crucial driving role in the onset and progression of diabetic nephropathy(DN).Ferroptosis is closely related to the damage of renal intrinsic cells in patients with diabetes.Chinese materia medica can improve DN by regulating the ferroptosis of renal intrinsic cells,with a good research and application prospect.This article reviewed the key regulatory factors and regulatory pathways of ferroptosis in DN,explained the"imbalance between yin and yang"of ferroptosis in DN based on TCM theories,and combed the research status of targeted inhibition of ferroptosis by active components of Chinese materia medica.The regulation of active components of Chinese materia medica on ferroptosis in DN has the characteristics of multiple targets,multiple links and integrity,which can provide a reference for the mechanism research and drug development of Chinese materia medica in treating DN.
