Research Progress in the Mechanism of Targeted Intervention of Chinese Materia Medica in PI3K/Akt Pathway for the Treatment of Fibrosis
10.19879/j.cnki.1005-5304.202311104
- VernacularTitle:中药靶向干预PI3K/Akt通路治疗纤维化机制研究进展
- Author:
Lei HAN
1
;
Shanshan LIN
;
Shuai WANG
;
Yingfei BI
;
Xianliang WANG
;
Jingyuan MAO
Author Information
1. 天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 300381;天津中医药大学,天津 301617
- Publication Type:Journal Article
- Keywords:
fibrosis;
Chinese materia medica;
signaling pathway;
pharmacological mechanism;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(3):180-185
- CountryChina
- Language:Chinese
-
Abstract:
Organ fibrosis is a chronic tissue injury caused by multiple causes,and the continuous dynamic progression will lead to abnormal organ structure and function.Recent studies have shown that Chinese materia medica can inhibit organ fibrosis by regulating the PI3K/Akt pathway,which holds potential significance for developing anti-fibrosis strategies.This article systematically reviewed the role of the PI3K/Akt signaling pathway in the entire process of fibrosis,and summarized the potential mechanisms of Chinese materia medica monomers,drug pairs and compounds that can target and intervene in PI3K/Akt signaling transduction in preventing and treating organ fibrosis,in order to provide reference for the intervention of Chinese materia medica in the PI3K/Akt pathway for the treatment of organ fibrosis.
