Study on TCM Syndrome Characteristics of Mild Cognitive Impairment in Coronary Heart Disease Based on Factor Analysis and Clustering Analysis
10.19879/j.cnki.1005-5304.202404408
- VernacularTitle:基于因子分析与聚类分析的冠心病轻度认知障碍中医证候特征研究
- Author:
Qing WANG
1
;
Yanfei LIU
;
Shihan XU
;
Fenglan LIU
;
Yue LIU
;
Fengqin XU
Author Information
1. 中国中医科学院西苑医院老年医学研究所,北京 100091;中国中医科学院西苑医院病证结合防治血管衰老重点研究室,北京 100091;中国中医科学院西苑医院国家中医心血管病临床医学研究中心,北京 100091
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
cognitive impairment;
TCM syndromes;
factor analysis;
clustering analysis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(2):137-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution characteristics of TCM syndromes in patients with mild cognitive impairment of coronary heart disease(CHD-MCI);To provide reference for the TCM prevention and treatment of CHD-MCI.Methods A prospective,cross-sectional study design was adopted to collect general information and TCM diagnosis information of CHD-MCI patients who attended Xiyuan Hospital of China Academy of Chinese Medical Sciences from July 2022 to December 2023.Descriptive statistics were conducted,retaining the main syndrome entries.Multivariate statistical methods such as factor analysis and clustering analysis were used to enrich and summarize the TCM syndrome characteristics of CHD-MCI patients and analyze their distribution patterns.Results This study collected information on the TCM four diagnostic methods from 220 CHD-MCI patients,retaining clinical syndrome items with a frequency of>20%,including 29 symptoms and 13 tongue pulse information.Common clinical symptoms included chest tightness,thirst,palpitations,chest pain,fatigue,severe physical activity or fatigue,dizziness and soreness in the waist and knees.Common tongue symptoms included greasy tongue coating,yellow tongue coating and dull red tongue.Common pulse conditions included pulse string,sinking pulse and astringency.Factor analysis was conducted on 42 variable items,obtaining 17 common factors with a cumulative contribution rate of 66.298%.Based on this,clustering analysis was applied,combined with clinical diagnosis and treatment experience and expert group opinions,to determine that there were four common types of TCM syndromes in CHD-MCI(ranked from high to low in proportion):kidney deficiency and blood stasis syndrome(38.18%),qi stagnation and blood stasis syndrome(28.18%),heart kidney deficiency syndrome(25.00%)and qi deficiency and phlegm obstruction syndrome(8.64%).Conclusion Patients with CHD-MCI can be classified into four types of TCM syndromes,with kidney deficiency and blood stasis syndrome being the most common.Based on the information from the TCM four diagnostic methods,the key points of each type of syndrome can be determined,providing a basis for the objective classification and differentiation of TCM syndromes in this disease.
