Research progress on volatile biomarkers in exhaled breath of lung cancer and their metabolic pathways

VernacularTitle:肺癌呼气挥发性标志物及其代谢途径的研究进展
Author: Wenmin SHI ¹ ; Lihua RU ; Wei LÜ ; Weisheng FENG ; Xiangqi WANG ; Zhijuan ZHANG
Author Information

1. 河南中医药大学药学院,河南郑州 450046
Publication Type:Journal Article
Keywords: Lung cancer; Volatile organic compound; Biomarker; Exhaled breath; Metabolism
From: Tumor 2024;44(10):1015-1032
CountryChina
Language:Chinese
Abstract: As a real-time,rapid and non-invasive method for monitoring the occurrence and development of various diseases and evaluating the health status of the body,breath detection has attracted wide attention in the application of early lung cancer screening.However,there is significant variability in the reported specific biomarkers of lung cancer,making it difficult to reach a unified consensus.Meanwhile,the pathways for the generation of volatile organic compounds(VOCs)in exhaled breath of lung cancer patients remain unclear,and further research on the detailed metabolic mechanisms is required.Therefore,this review comprehensively summarizes the VOCs detected in the exhaled breath of lung cancer patients from relevant literature in the past five years,deeply analyzes the production mechanism of these VOCs and the internal correlation with the disease,and evaluates the performance of the lung cancer prediction models constructed based on these VOCs,in order to provide reference for clinical and subsequent researches.