Correlation of bone metabolic markers with severity of aortic calcification and risk for cardiovascular events in elderly peritoneal dialysis patients
10.3969/j.issn.1009-0126.2025.02.005
- VernacularTitle:骨代谢标志物与老年腹膜透析患者主动脉钙化程度和心血管事件发生风险的相关性
- Author:
Jinxiu CHENG
1
;
Yanchun CAO
;
Shengjun LIU
;
Yujie JIN
;
Hua LIU
;
Linlin WANG
;
Shaoqiang QIN
Author Information
1. 075000 张家口,河北北方学院附属第一医院肾内科
- Publication Type:Journal Article
- Keywords:
peritoneal dialysis;
vascular calcification;
correlation of data;
logistic model
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between novel bone metabolism markers and the degree of aortic calcification as well as cardiovascular event risk in elderly patients treated by PD.Methods A prospective trial was conducted on 230 elderly patients receiving continuous am-bulatory PD in our department from February 2022 to February 2024.According to the occur-rence of cardiovascular events during dialysis treatment,they were divided into a cardiovascular event group(n=92)and a control group(n=138).Relevant clinical data were collected,aortic calcification was assessed using AAC scores,and serum levels of bone metabolism markers,inclu-ding osteoprotegerin,TRACP,and PINP were measured.Results The serum levels of osteoprote-gerin,TRACP and PINP were significantly higher in the cardiovascular event group than the con-trol group(P＜0.01).The cardiovascular event group had obviously severe calcification and higher AAC score than the control group(P＜0.01).The serum levels of the three bone metabolism markers were notably higher in the patients with severe calcification than those with moderate calcification,followed by mild calcification in turn(P＜0.01).Spearman correlation analysis indi-cated that the levels of the three indicators were positively correlated with the degree of aortic cal-cification in elderly PD patients(r=0.465,P=0.000;r=0.396,P=0.000;r=0.434,P=0.000).Multivariate logistic regression analysis showed that these three indicators were risk factors for cardiovascular events in elderly PD patients(P＜0.01).Conclusion The three bone metabolism markers are significantly correlated with aortic calcification severity and cardiovascular event risk in elderly PD patients.Monitoring these marker levels may be helpful for the assessment and man-agement of cardiovascular risk.
