Advances in lymph node metastasis in primary malignant bone tumors
10.3781/j.issn.1000-7431.2024.2312-0639
- VernacularTitle:淋巴结转移在原发恶性骨肿瘤中的研究进展
- Author:
Kai LUO
1
;
Tianyu XIE
;
Qingjun WEI
;
Yun LIU
Author Information
1. 广西医科大学第一附属医院脊柱骨病外科,广西壮族自治区 南宁 530021
- Publication Type:Journal Article
- Keywords:
Malignant bone tumors;
Primary;
Lymph node metastasis;
Metastasis pathway
- From:
Tumor
2024;44(10):1051-1060
- CountryChina
- Language:Chinese
-
Abstract:
Currently,common primary malignant bone tumors in clinical practice include osteosarcoma,chondrosarcoma,Ewing's sarcoma,chordoma,and multiple myeloma.Malignant bone tumors often metastasize to the lungs through the bloodstream,but lymph node metastasis can also occur.Once lymph node metastasis occurs,the prognosis for patients is worse than with lung metastasis,making the study of lymph node metastasis in malignant bone tumors a growing research focus in recent years.According to current research,primary malignant bone tumors mainly metastasize to lymph nodes through two pathways:firstly,bone tumor cells break through the periosteum into the surrounding lymphatic tissue;secondly,they regulate the expression of VEGF-C by secreting factors like WISP-3,CCL5,BDNF,thus inducing the neogenesis of lymphatic vessels in malignant bone tumors.Past research on lymph node metastasis of primary malignant bone tumors has mostly focused on clinical studies of a single type of malignant bone tumor,lacking systematic basic research and reviews,and the mechanisms of metastasis are not yet fully elucidated.Moreover,different types of malignant bone tumors vary in their rates and sites of lymph node metastasis.Therefore,this article mainly reviews the rates,sites,diagnostic methods,potential mechanisms,and treatment methods of lymph node metastasis in these five common types of malignant bone tumors,aiming to deepen understanding of lymph node metastasis in primary malignant bone tumors and to provide new ideas for clinical treatment and drug development.
