The current research status of ataxia telangiectasia mutated gene in the treatment of bladder cancer
10.3781/j.issn.1000-7431.2024.2403-0123
- VernacularTitle:共济失调毛细血管扩张突变基因在膀胱癌治疗中的研究现状
- Author:
Longmei FAN
1
;
Jiajia TANG
;
Tianyu HUANG
;
Yuanjian LIAO
;
Mingshun ZUO
;
Neng ZHANG
;
Jiangrong ZHANG
Author Information
1. 遵义医科大学附属医院泌尿外科,贵州 遵义 5630006;遵义医科大学护理学院,贵州 遵义 5630006
- Publication Type:Journal Article
- Keywords:
Bladder cancer;
Ataxia telangiectasia mutated;
DNA damage;
Targeted therapy
- From:
Tumor
2024;44(10):1044-1050
- CountryChina
- Language:Chinese
-
Abstract:
The ataxia telangiectasia mutated(ATM)gene is an important tumor suppressor gene and a key effector gene in regulating the repair of double-strand DNA breaks.It plays an indispensable role in maintaining genetic stability,facilitating cell cycle arrest,and modulating cell apoptosis.When the ATM gene mutates,it fails to effectively induce the phosphorylation of downstream targets,leading to impaired DNA repair mechanisms,genetic instability,and chromosomal structural abnormalities,ultimately promoting abnormal proliferation of tumor cells.Analysis of next-generation sequencing(NGS)datas reveals a relatively high mutation rate of the ATM gene in bladder cancer cells.Relevant studies have shown that ATM gene regulates the proliferation,invasion,and metastasis of bladder cancer cells through the signaling pathways such as nuclear transcription factor-κB(NF-κB)and Interferon-γ(IFNγ).Mutanted ATM gene can enhance patients'sensitivity to radiotherapy and chemotherapy,and boost the efficacy of immunotherapy,resulting in a generally better prognosis for patients with ATM gene mutation.This finding marks ATM gene as a potential therapeutic target and predictive prognosis biomarker for bladder cancer patients.Therefore,this article will comprehensively review the research on the ATM gene in bladder cancer from 3 aspects:the structural characteristics of the ATM gene and its tumor-suppressing and tumor-promoting functions,the mechanism of action of the ATM gene in the occurrence and development of bladder cancer,and the impact of the ATM gene on the treatment and prognosis of bladder cancer patients.Additionally,the future research directions of the ATM gene was prospected,with the aim of providing new targets for the drug treatment of bladder cancer,and bringing new hope for the treatment of bladder cancer patients.
