Effects of immersion hypothermia and body temperature afterdrop during rewarming on animal bodies
10.3760/cma.j.cn311847-20201014-00388
- VernacularTitle:浸泡性冻僵及复温时"体温后降效应"对机体的影响研究
- Author:
Shulin LIU
1
;
Wen CAO
1
;
Yongjie YAO
1
;
Zhiyong PENG
1
;
Shenglong DAI
1
;
Kehua LI
1
;
Jie LIN
1
;
Gaochao SI
1
Author Information
1. 200433 上海，海军军医大学海军特色医学中心航空医学研究室
- Publication Type:Journal Article
- Keywords:
Low temperature seawater immersion;
Body temperature afterdrop effect;
Heart rate;
Blood glucose;
Liver function;
Kidney function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(3):336-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of immersion hypothermia and body temperature afterdrop during rewarming on animal bodies by establishing animal body temperature afterdrop model.Methods:The mini-swine were submerged in the simulated low temperature seawater (1.0℃) from the chest down. When their body temperatures dropped to 28.0℃, they were immediately removed from the seawater and placed in the warm water of 35.0℃ for rewarming. The body temperature, electrocardiogram, and heart rate were real-time monitored. Blood samples were collected before the mini-swine entering the seawater, when being removed from the seawater, and when the ventricular fibrillation occurred as a result of body temperature afterdrop. The levels of blood glucose, platelets, blood urea nitrogen, creatinine, serum potassium, total bilirubin, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), cold shock protein (CSP), and adrenaline were measured.Results:As the seawater immersion went on, the body temperatures of the mini-swine gradually decreased and their heart rates gradually increased. But the heart rates began to decrease when the body temperature dropped to an average of 35.5℃. During rewarming, the body temperature continued to drop, then began to rise from the lowest average of 25.3℃. The average body temperature afterdrop was 2.7℃. The heart rates began to rise from the lowest average of 50 beats per minute. When the body temperature rose to an average of 37.1℃, the heart rates returned to an average of 112 beats per minute. Compared with the values before seawater immersion, the blood glucose, blood urea nitrogen, creatinine, total bilirubin, serum potassium, AST, and CSP of the mini-swine were significantly increased when they were removed from the seawater, with statistically significant differences ( P<0.05). Compared with the values at the removal from seawater, when the ventricular fibrillation caused by the afterdrop occurred, the blood glucose level was significantly reduced, while the values of blood urea nitrogen, creatinine, total bilirubin, and AST were significantly increased, with statistically significant differences ( P<0.05), but the values of platelet, LDH, and adrenaline had no significant changes. Conclusion:Low temperature seawater immersion and body temperature afterdrop significantly affect heart rate, blood glucose, and liver and kidney functions, which can provide a theoretical basis for preventing and treating temperature afterdrop during rewarming in patients with hypothermia.
