Research progress on lactylation modifications in colorectal cancer
10.12354/j.issn.1000-8179.2025.20250701
- VernacularTitle:乳酸化修饰在结直肠癌中的研究进展
- Author:
Zhou WEITAO
1
;
Gu DONGYING
1
Author Information
1. 南京市第一医院(南京医科大学附属南京医院)肿瘤内科(南京市 210000)
- Publication Type:Journal Article
- Keywords:
histone lactation;
non-histone lactation;
colorectal cancer;
drug resistance
- From:
Chinese Journal of Clinical Oncology
2025;52(13):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer,one of the most common malignant tumors worldwide,involves various complex pathophysiological processes.With the in-depth study of molecular science,weidentified lactylation,a new post-translational protein modification,as a key regulator in the initiation and progression of colorectal cancer.Lactylation refers to the modification of lysine residues in proteins by the addition of lactyl groups derived from lactic acid.As a glycolytic end product,lactate accumulates in the tumor microenvironment and regulates gene expres-sion and cellular function by inducing lactylation of histone and non-histone proteins.This article describes how lactylation modification drives tumor immune evasion,metabolic reprogramming,and angiogenesis through epigenetic mechanisms,and elaborates on its impact on the occurrence,metastasis,and multidrug resistance in colon cancer.
