Research progress on using CRISPR Gene-Editing Organoids to study the fundamental transformation of pancreatic cancer
10.3781/j.issn.1000-7431.2024.2404-0222
- VernacularTitle:CRISPR基因编辑类器官在胰腺癌基础转化中的研究进展
- Author:
Tao LIU
1
;
Jinxin TAO
1
;
Taiping ZHANG
1
Author Information
1. 中国医学科学院北京协和医学院北京协和医院基本外科,北京 100730
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Organoids;
CRISPR;
Gene editing
- From:
Tumor
2024;44(12):1209-1215
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a malignant tumor with extremely poor prognosis,and its biological behavior is closely related to its genetic characteristics.Traditional preclinical research models struggle to accurately simulate the complex genetic heterogeneity and histological characteristics of pancreatic cancer.In recent years,the development of organoid models and CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)technology has provided new tools for pancreatic cancer research.Organoids can simulate the genetic and histological features of primary tumors,while CRISPR technology enables precise genetic manipulation in organoids.CRISPR Gene-Editing Organoids can model the occurrence and evolution of pancreatic cancer,conduct gene function analysis,and perform drug screening.This review discusses the recent advancements in the application of organoid models combined with CRISPR technology in pancreatic cancer research,which are expanding our understanding of pancreatic cancer.
