Predictive value of prognostic nutrition index and construction of a nomogram for survival in elderly patients with non-small cell lung cancer receiving radiotherapy
10.3760/cma.j.issn.0254-9026.2025.03.013
- VernacularTitle:预后营养指数对接受放疗的老年非小细胞肺癌患者生存的预测价值及列线图的构建
- Author:
Xingyu DU
1
;
Tongmei ZHANG
;
Cuimeng TIAN
Author Information
1. 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所 放射治疗科，北京 101149
- Publication Type:Journal Article
- Keywords:
Prognosis nutritional index;
Radiotherapy;
Non-small cell lung cancer;
Elderly patients
- From:
Chinese Journal of Geriatrics
2025;44(3):317-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of prognostic nutrition index(PNI)in the overall survival of patients with non-small cell lung cancer(NSCLC)aged 70 years and above treated with radiotherapy, and to construct a nomogram prediction model.Methods:General clinicopathological features and routine blood test in144 patients with pathologically confirmed NSCLC aged 70 years and above were collected, PNI(serum albumin+ 5× lymphocyte count)before radiotherapy were calculated, and prognostic factors affecting the survival were analyzed.Build a nomogram model and verify it.Statistical analysis was performed using R language 4.0.3 software.Results:125 elderly patients with NSCLC met the inclusion criteria, with the median survival time of 18.4 months.The optimal cutoff value of PNI was 42.3.PNI was closely correlated with age, chemotherapy, immunotherapy and radiation pneumonia in elderly NSCLC patients receiving radiotherapy( P<0.05).TNM stage, chemotherapy, immunotherapy and PNI were independent factors affecting the prognosis of NSCLC patients aged 70 years and above who had received radiotherapy( P<0.05).We use these independent risk factors to construct prognostic column charts at 1, 2, and 3 years.We use Bootstrap repeated sampling 1000 times, and validate through ROC curves and calibration curves. Conclusions:For NSCLC patients aged 70 years and above who have received radiotherapy, PNI is a simple prognostic indicator and has practical clinical application value.
