Frailty trajectory and risk factors in elderly hemodialysis patients after SARS-CoV-2 infection
10.3760/cma.j.issn.0254-9026.2025.02.010
- VernacularTitle:老年血液透析患者合并新型冠状病毒感染后衰弱变化及影响因素的探究
- Author:
Yifan YANG
1
;
Huayu YANG
;
Zongli DIAO
;
Xu LIU
;
Lan YAO
;
Liyan WANG
;
Xiaotian SHI
;
Xu LI
;
Qing MA
Author Information
1. 首都医科大学附属北京友谊医院老年医学科，北京 100050
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
Hemodialysis;
Frailty
- From:
Chinese Journal of Geriatrics
2025;44(2):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the trajectory of frailty in elderly patients on maintenance hemodialysis(MHD)following SARS-CoV-2 infection and its associated risk factors.Methods:This prospective cohort study focused on elderly patients who underwent baseline frailty assessment(T0)during hemodialysis treatment at Beijing Friendship Hospital for over 3 months between December 1st, 2022, and December 31th, 2022, and were diagnosed with SARS-CoV-2 infection.The Fried Frailty Phenotype was evaluated at 1 month(T1), 3 months(T2), and 6 months(T3)post-infection.Frailty trajectory after infection was analyzed using repeated measurement ANOVA.Patients were divided into stable/improvement or exacerbation groups based on their frailty status at T0 and T3, with logistic regression analysis employed to identify risk factors for different frailty trajectories.Results:A total of 130 elderly maintenance hemodialysis patients, with a median age of 66 years(range: 63-71 years)and 62 males(47.7%), were included in the study.Six months after the infection, a majority of surviving patients saw their frailty scores return to baseline levels.Specifically, 72 patients(55.4%)either maintained or improved to robust or pre-frail states, while 9 patients(6.9%)progressed to a pre-frail state, 18 patients(13.8%)progressed to a frail state, and 31 patients(23.8%)remained in a frail state.Results from multivariate logistic regression analysis indicated that low grip strength( OR: 6.30, 95% CI: 1.48-26.73)and all-cause hospitalization( OR: 5.01, 95% CI: 1.19-21.03)were identified as risk factors for non-frail patients transitioning to frailty( P<0.05). Conclusions:The majority of elderly maintenance hemodialysis patients who survived SARS-CoV-2 infection returned to their baseline level of frailty or showed improvement within 6 months.Non-frail patients with low grip strength or those who were hospitalized were more likely to deteriorate towards frailty.
