Effects of hyperbaric oxygen therapy on immune function and quality of life of patients with breast cancer undergoing radiochemotherapy
10.3760/cma.j.cn311847-20191210-00380
- VernacularTitle:高压氧治疗对乳腺癌放化疗患者术后并发症及免疫功能的影响
- Author:
Caifeng LIN
1
;
Juying CHEN
;
Xiaoying LIN
;
Linwen ZHENG
Author Information
1. 350007 福州，福建省立金山医院普外科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Breast cancer;
Radiochemotherapy;
Immune function;
Complication
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(2):209-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of hyperbaric oxygen (HBO) therapy on immune function and quality of life in patients with breast cancer undergoing radiochemotherapy.Methods:A total of 100 breast cancer patients admitted in the Department of General Surgery of Fujian Provincial Hospital South Branch from the February of 2015 to the February of 2018 were selected as the study objects, and were divided into observation group and control group according to the random number table method, with 50 cases in each group. Patients in the control group were treated with chemoradiotherapy and other routine clinical symptomatic treatments. Patients in the observation group were treated with HBO therapy on the basis of the treatments of the control group. One week after treatment, the occurrence of ischemic necrosis of flap, subcutaneous hydrops, incision infection, and edema of the affected limbs were all evaluated and recorded. After 5 courses of treatment, the changes of WBC, PLT, hemoglobin content, and serum immune function indexes, CD4 + , CD8 + , and CD4 + /CD8 + of both the two groups before and after treatment were detected and compared. Results:After 5 courses of treatment, the occurrence of ischemic necrosis of flap, subcutaneous hydrops, incision infection, and edema of the affected limbs of the observation group were significantly lower than those of the control group (χ 2=8.073, P<0.01). WBC and PLT counts, hemoglobin content in the observation group were significantly higher than those in the control group( P<0.05). Compared with the control group, CD4 + , CD8 + and CD4 + /CD8 + were significantly increased in the observation group ( P<0.05). Conclusion:HBO therapy can improve the immune function indexes of breast cancer patients after radiochemotherapy and increase PLT, WBC count, and hemoglobin content, so as to significantly reduce the incidence of postoperative complications, which is worthy of popularization and application in clinic.
