The timing of hyperbaric oxygen intervention in cerebral infarction and its influence on medium and long term prognosis
10.3760/cma.j.cn311847-20191112-00314
- VernacularTitle:高压氧治疗脑梗死患者介入时机的选择及对中远期预后的影响
- Author:
Tiandong WANG
1
;
Zhanjun REN
Author Information
1. 030001 太原，山西医科大学第一医院
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Cerebral infarction;
Long-term prognosis;
Intervention timing
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(2):180-183,204
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the timing of hyperbaric oxygen intervention in cerebral infarction and its impact on medium and long term prognosis.Methods:A total of 48 patients with cerebral infarction who underwent hyperbaric oxygen (HBO) therapy in the Third Affiliated Hospital of Qiqihar Medical University from the September of 2016 to the July of 2019 were included in the observation group. Another 48 patients with cerebral infarction who were not treated with HBO were included in the control group. Patients who received HBO≤7 d were included into the early HBO group, and those who received HBO>7 d were included into the late HBO group. Cerebral blood flow index and neurological deficit score (NIHSS) before and after the treatment as well as the good prognosis rate after 3 months were recorded. The risk factors affecting the prognosis of the patients with cerebral infarction after 3 months were analyzed.Results:After 3 courses of the treatment, the blood flow velocities of the anterior, posterior, and middle arteries of the observation group were higher than those of the control group; the resistance indexes were lower than those of the control group, and the NIHSS score was lower than that of the control group ( P<0.05). The blood flow velocities of the anterior, posterior, and middle arteries in the early HBO group were higher than those in the late HBO group; the resistance indexes of the early HBO group were lower than those of the late HBO group; and the NIHSS score of the early HBO group was lower than that of the late HBO group ( P<0.05). The prognosis of the observation group (77.08%) was significantly higher than that of the control group (54.17%); the prognosis of the early HBO group (86.96%) was significantly higher than that of the control group (68.00%). All the differences were statistically significant ( P<0.05). By unifactorial analysis and further Logistic regression analysis, it was confirmed that onset time, NIHSS score on admission, intracranial artery stenosis, and HBO intervention timing were the independent factors affecting the prognosis of cerebral infarction at 3 months ( P<0.05 or P<0.01). Conclusion:HBO therapy for cerebral infarction can further improve the cerebral blood flow parameters of patients and alleviate neurological defects, which can significantly improve the medium and long term prognosis.
