Effect of hyperbaric oxygen therapy on serum VEGF and IGF-1 in patients with elder diabetic retinopathy
10.3760/cma.j.cn311847-20191118-00328
- VernacularTitle:高压氧治疗对老年糖尿病视网膜病变患者血清VEGF、IGF-1水平的影响
- Author:
Yan DAI
1
;
Ping HU
1
;
Mingqin GE
1
;
Fuyuan LI
1
Author Information
1. 276400 山东省临沂，临沂市中心医院内分泌科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Diabetic retinopathy;
C-reactive protein;
Vascular endothelial growth factor;
Insulin like growth factor-1
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(2):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of hyperbaric oxygen (HBO) therapy on serum VEGF and IGF-1 in patients with elder diabetic retinopathy.Methods:A total of 114 patients with elder diabetic retinopathy admitted in Linyi Central Hospital from the May of 2016 to the May of 2018 were selected and randomly divided into observation group and control group according to the random number table method, with 57 patients in each group. The control group received routine treatments, i. e. calcium dobesilate, while the observation group received HBO combined with the routine treatment as the control group. After 3 courses of treatment, the changes of serum high-sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF), and type-1 insulin like growth factor (IGF-1) of each group were compared before and after the treatment. The effects of retinopathy severity after treatment in each group on the levels of serum hs-CRP, VEGF, and IGF-1 were also observed.Results:The therapeutic efficacy rate of the observation group (78.39%) was significantly higher than that of the control group (56.77%), with statistical difference ( χ2=4.524, P<0.05). After 3 courses of the treatment, the expression levels of hs-CRP, VEGF, and IGF-1 of the two groups were significantly lower than those before the treatment. Furthermore, the expression levels of hs-CRP, VEGF and IGF-1 in the observation group were significantly lower than those in the control group, with statistical difference( P<0.01). Among the patients with Grade I and II retinopathy, the serum hs-CRP, VEGF, and IGF-1 in the observation group were significantly lower than those in the control group, and the differences were statistically significant ( P<0.05). Among the patients with Grade III and IV retinopathy, there was no statistical difference comparing those values between the two groups ( P>0.05). Conclusion:In the treatment of elder diabetic retinopathy, HBO assisting calcium dobesilate is more effective than singly using calcium dobesilate, and decreases serum hs-CRP, VEGF and IGF-1 levels.
