Effects of persistent stress of long oceangoing voyage on the immune function and cytokine expression in submarine crew
10.3760/cma.j.issn.1009-6906.2020.01.006
- VernacularTitle:长远航持续应激对潜艇艇员免疫功能及细胞因子表达的影响
- Author:
Qingju SUN
1
;
Huawei YU
1
;
Jun WANG
1
;
Bing LIANG
1
Author Information
1. 266071 山东省青岛，解放军第九七一医院检验科
- Publication Type:Journal Article
- Keywords:
Long oceangoing voyage;
Lymphocyte;
Regulatory T cells;
Cytokine;
Immune function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes of the lymphocyte subpopulation, regulatory T cells, and related cytokines before and after long oceangoing voyage, and to explore the effect of persistent stress on immune function in submarine crew.Methods:Sixty-one submariners of long oceangoing voyage (70 d) were selected randomly. Before and after the voyage, the quantities of lymphocyte subpopulations [CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , CD3 -CD19 + , CD3 -CD(16+ 56) + ] and regulatory T cells(CD4 + CD25 + ) from peripheral blood were detected by flow cytometry; and the contents of interleukin-2(IL-2), interleukin-14(IL-14), interleukin-8(IL-8), and interferon inducible protein 10(IP-10) were detected and compared by liquid chip. Results:Compared with those before voyage, the levels of CD3 + , CD4 + /CD8 + , CD3 -CD19 + , CD3 -CD(16+ 56) + decreased significantly ( P<0.05), CD4 + /CD8 + and CD4 + CD25 + increased significantly( P<0.01). The contents of IL-2 and IL-8 were lower markedly than those before voyage( P<0.05), while the contents of IL-4 andIP-10 were higher than those before voyage ( P<0.05). Conclusion:The immune function of submarine crew had some obvious changes under persistent stress of long oceangoing voyage, indicating long oceangoing voyage had certain effects on the health of submarine crew; which is necessary to make further research on the mechanism and take preventive measures.
