Mechanisms of astrocyte-mediated immune evasion in brain metastatic melanoma
10.3760/cma.j.cn114453-20240105-00009
- VernacularTitle:星形胶质细胞促进脑转移黑色素瘤免疫逃逸的机制
- Author:
Ayoujiang AYIDANA
1
;
Tianyi LIU
1
Author Information
1. 复旦大学附属华东医院整形外科 上海市老年医学临床重点实验室 上海市老年医学研究所，上海 200040
- Publication Type:Journal Article
- Keywords:
Melanoma;
Brain metastatic;
Astrocytes;
Neoplasm metastasis;
Tumor immune escape
- From:
Chinese Journal of Plastic Surgery
2025;41(10):1088-1092
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is a highly malignant tumor characterized by strong invasiveness and a high propensity for brain metastasis. Astrocytes can suppress antitumor immune responses through multiple pathways, thereby establishing an immunosuppressive microenvironment that supports tumor cell survival and promotes immune evasion of brain metastatic melanoma cells. This article reviewed the molecular mechanisms by which astrocytes facilitated immune evasion in brain metastatic melanoma in recent years, aiming to provide insights for identifying novel biomarkers and therapeutic targets for melanoma brain metastasis.
