The research progress on stress-induced grey hair
10.3760/cma.j.cn114453-20240523-00138
- VernacularTitle:应激诱发白发的研究进展
- Author:
Fangqi TANG
1
;
Ling ZHOU
;
Weiming QIU
Author Information
1. 武汉科技大学医学院，武汉 430062
- Publication Type:Journal Article
- Keywords:
Stress;
Melanocytes;
Receptors, neurotransmitter;
Gray hair;
Oxidative stress;
Inflammatory reaction
- From:
Chinese Journal of Plastic Surgery
2025;41(9):986-994
- CountryChina
- Language:Chinese
-
Abstract:
As the pace of life accelerates, the incidence of grey hair increases significantly along with stress. However, the exact mechanism of hair graying remains unclear. Hair graying is not only a prominent marker of human aging but also closely associated with various serious systemic diseases, such as coronary heart disease and hypertension. Therefore, we review the mechanism of stress-induced hair graying as follow by searching the key words stress and grey hair. (1)Acute and chronic stressors promote the sympathetic nerve to release neurotransmitters(norepinephrine and P substance), which causes the exhaustion of melanocyte stem cells and hair greying. (2)Stress directly or indirectly promotes melanocyte apoptosis by inducing oxidative stress.(3)Stress disrupts melanogenesis by inducing the product of inflammatory factors and immune response to kill melanocytes, and regulating intracellular signaling. Our review is expected to provide a theoretical reference for the prevention and treatment of gray hair.
