The role of astrocyte in melanoma brain metastases
10.3760/cma.j.cn114453-20240105-00008
- VernacularTitle:星形胶质细胞促进黑色素瘤脑转移研究进展
- Author:
Ayoujiang AYIDANA
1
;
Tianyi LIU
1
Author Information
1. 复旦大学附属华东医院整形外科 上海市老年医学临床重点实验室 上海市老年医学研究所，上海 200040
- Publication Type:Journal Article
- Keywords:
Melanoma;
Astrocytes;
Brain neoplasms;
Neoplasm metastasis;
Tumor microenvironment;
Signal transduction
- From:
Chinese Journal of Plastic Surgery
2025;41(8):885-888
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma brain metastases are associated with high incidence and poor prognosis, with their processes of dissemination, colonization, and growth closely influenced by the brain microenvironment. As one of the major cell types in the brain parenchyma, astrocytes facilitate melanoma brain metastasis through multiple mechanisms. Astrocyte-derived factors such as CXCL10, CCL17, NGF, and NT-3 promote the migration of melanoma cells toward the brain. In addition, astrocytes secrete inflammatory cytokines that enhance tumor cell translocation across the blood-brain barrier, and they further support melanoma cell proliferation in the brain via gap junction formation and secretion of unsaturated fatty acids. A deeper understanding of these mechanisms may provide novel insights into the pathogenesis and targeted therapy of melanoma brain metastasis.
