Preconditioning strategies for adipose-derived mesenchymal stem cells
10.3760/cma.j.cn114453-20240423-00105
- VernacularTitle:脂肪间充质干细胞预处理研究
- Author:
Wenqian YANG
1
;
Lin KANG
;
Xiao LONG
Author Information
1. 中国医学科学院北京协和医学院，北京 100005
- Publication Type:Journal Article
- Keywords:
Regenerative medicine;
Adipose-derived stem cells;
Preconditioning;
Hypoxia;
Paracrine function;
Cell-based therapy
- From:
Chinese Journal of Plastic Surgery
2025;41(8):865-874
- CountryChina
- Language:Chinese
-
Abstract:
Adipose-derived mesenchymal stem cells (ADSCs) are prominent candidates for regenerative medicine owing to their accessibility and multilineage differentiation potential. Nonetheless, clinical translation is limited by poor survival, differentiation, and migration after transplantation. To overcome these challenges, various pretreatment strategies have been developed to enhance their therapeutic efficacy. This review summarizes recent advances in ADSC pretreatment, focusing on methods that improve their survival, integration, and function in therapeutic applications. Physical, chemical, and biological pretreatments are discussed, including hypoxic conditioning, pharmacological interventions, and cytokine pre-incubation, all of which serve to precondition ADSCs for enhanced regenerative performance. These developments hold promise for enhancing the therapeutic potential of ADSCs and offer new opportunities for their future clinical application.
