Serum sickness-like reaction due to intramuscular injection of botulinum antitoxin type A: a case report
10.3760/cma.j.cn114453-20250305-00052
- VernacularTitle:肌肉注射A型肉毒抗毒素致血清病样反应1例
- Author:
Yali HU
1
;
Xuhan SUN
1
;
Lijia WANG
1
;
Zhengya ZHANG
1
;
Lanlan CHEN
1
;
Hailong YU
1
Author Information
1. 江苏省苏北人民医院神经内科，扬州 225001
- Publication Type:Journal Article
- Keywords:
Botulinum toxins;
Botulinum antitoxin;
Poisoning;
Serum sickness-like reaction;
Intramuscular injection
- From:
Chinese Journal of Plastic Surgery
2025;41(8):855-859
- CountryChina
- Language:Chinese
-
Abstract:
In October 2024, a 36-year-old female patient with botulinum toxin type A intoxication for 15d was admitted to the Department of Neurology of Northern Jiangsu People’s Hospital. Although type A botulinum antitoxin (BAT) therapy remained effective, the patient developed a serum sickness-like reaction (SSLR) on day 4 of treatment after receiving eight consecutive desensitizing intramuscular injections of BAT. After stopping the injection of the drug and giving intravenous dexamethasone, the patient’s symptoms improved. On the 6th day after stopping the injection of botulinum antitoxin type A, the patient was followed up in the outpatient clinic and the skin symptoms had almost disappeared. This article analyzed the patient’s medical records and explored the association between BAT and SSLR, suggesting that medical personnel should be alert to the risk of adverse reactions when applying antitoxin therapy, and that they should identify and intervene in a timely manner in order to ensure the safety of the medication and therapeutic efficacy of the patients.
