Cerebrospinal fluid flow dynamics and volume changes of pulsatile tinnitus patients caused by sigmoid sinus wall dehiscence based on MRI
10.3760/cma.j.cn112149-20240919-00572
- VernacularTitle:基于MRI的乙状窦沟骨板缺损性耳鸣患者脑脊液流场及体积变化特征
- Author:
Lanyue CHEN
1
;
Wei LI
;
Xiaobo MA
;
Xiaoxia QU
;
Mengdi ZHOU
;
Xiwen WANG
;
Shanbin SUN
;
Zhaohui LIU
Author Information
1. 首都医科大学附属北京同仁医院放射科，北京100730
- Publication Type:Journal Article
- Keywords:
Tinnitus;
Magnetic resonance imaging;
Sigmoid sinus wall dehiscence;
Cerebrospinal fluid;
Phase-contrast
- From:
Chinese Journal of Radiology
2025;59(8):917-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate cerebrospinal fluid (CSF) flow dynamics and volume changes of pulsatile tinnitus (PT) patients induced by sigmoid sinus wall dehiscence (SSWD) using MRI.Methods:This was a cross-sectional study. Totally 55 SSWD-PT patients, and 35 age- and sex-matched healthy controls were prospectively enrolled at Beijing Tongren Hospital, Capital Medical University from October 2019 to September 2023. The CSF at the midbrain aqueduct level was analyzed based on phase-contrast MRI to obtain the flow dynamics information. Based on T 1-weighted turbo field echo sequence, the CSF was segmented and the volume of CSF was calculated using ITK-SNAP software. The Mann-Whitney U test was used to compare the differences of each parameter between the two groups. Binary logistic regression was used to analyze the parameters with statistically significant differences to obtain the independent influencing factors of SSWD-PT and establish the combined parameters. Receiver operating characteristic curve analysis was used to evaluate the efficacy of diagnosing SSWD-PT. Results:Compared with controls, the SSWD-PT group showed significantly decreased mean flux (MF), mean velocity, peak velocity( P<0.05), and significantly increased regurgitant fraction (RF), CSF volume ( P<0.05). No significant differences were observed in forward flow volume, backward flow volume, and stroke volume ( P>0.05). The logistic regression results showed that MF ( OR=0.497, 95% CI 0.305-0.808, P=0.005) and RF ( OR=1.809, 95% CI 1.040-3.147, P=0.036) were independent influencing factors of SSWD-PT. The area under the curve (AUC) of MF and RF for diagnosing SSWD-PT were 0.641 (95% CI 0.517-0.766) and 0.675 (95% CI 0.564-0.786), respectively. The AUC of the combination of MF and RF was 0.724 (95% CI 0.614-0.833). Conclusions:SSWD-PT patients have abnormal changes in CSF flow dynamics and volume. The MF and RF demonstrate moderate diagnostic value for diagnosing SSWD-PT.
