Prognostic value of thoracic aorta and aortic valve CT calcification volume scores in patients undergoing transcatheter aortic valve implantation
10.3760/cma.j.cn112149-20241117-00684
- VernacularTitle:胸主动脉及主动脉瓣CT钙化体积积分对经导管主动脉瓣植入术患者的预后评估价值
- Author:
Huimin GUO
1
;
Lifei XING
;
Haibo HU
;
Yinghui GE
Author Information
1. 河南省心脏病影像医学重点实验室 阜外华中心血管病医院放射科，郑州451464
- Publication Type:Journal Article
- Keywords:
Tomography, X-ray computed;
Aortic valve stenosis;
Transcatheter aortic valve implantation;
Calcification;
Prognosis
- From:
Chinese Journal of Radiology
2025;59(8):930-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the prognostic impact of the thoracic aorta and aortic valve calcification volume (TAC, AVC) score based on CT measurementsin patients undergoing transcatheter aortic valve implantation (TAVI).Methods:We retrospectively analyzed 102 patients who underwent TAVI for severe aortic stenosis from March 2018 to April 2022 at Fuwai Central China Cardiovascular Hospital. The patients were stratified into low TAC and AVC group (TAC low, AVC low) and high TAC and AVC group (TAC high, AVC high) based on median TAC and AVC. The independent risk factors affecting the prognosis of TAVI patients were analyzed using univariate and multivariate Cox proportional risk regression, and the independent risk factors affecting the prognosis of TAVI were analyzed by survival curve. Results:A total of 102 patients were included with a median follow-up of 695 (602, 923) days, during which 9 (8.8%) all-cause deaths and 33 (32.4%) composite end-point events occurred. Univariate Cox risk regression analysis found that TAC was a risk factor for all-cause mortality events in TAVI patients ( P=0.039), TAC and AVC were risk factors for composite endpoint events in TAVI patients ( P=0.047, 0.035).TAC was an independent predictor of all-cause mortality after TAVI in multivariate analysis ( HR=8.971, 95% CI 1.121-71.790, P=0.039), and TAC and AVC were independent risk factors for composite endpoint events after TAVI ( HR=2.243, 95% CI 1.099-4.578, P=0.026; HR=2.346, 95% CI 1.146-4.804, P=0.020). Kaplan-Meier survival curves showed that high TAC and AVC scores increased the risk of end-point events ( P<0.05). Conclusion:CT-quantified TAC and AVC volume scores are independent prognostic markers in TAVI patients, with greater calcification burden portending poorer clinical outcomes.
