Reprogramming regulates macrophage polarization and functional transformation to promote diabetic wound healing
10.3760/cma.j.cn114453-20230811-00023
- VernacularTitle:重编程调节巨噬细胞极化及功能转换促进糖尿病创面愈合
- Author:
Dan SUN
1
;
Feng LU
1
;
Qiang CHANG
1
Author Information
1. 南方医科大学南方医院整形外科，广州 510515
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Macrophages;
Wound healing;
Polarization;
Reprogramming;
Biomaterial
- From:
Chinese Journal of Plastic Surgery
2025;41(1):98-106
- CountryChina
- Language:Chinese
-
Abstract:
Delayed wound healing in diabetes, which is caused by systemic metabolic disorders and local chronic inflammation, is a common complication of the disease. A critical issue is the impaired polarization of macrophages during the wound healing process, leading to prolonged inflammation and hindering the transition to the repair phase. This review systematically summarizes the polarization states of macrophages in diabetic wounds and their essential roles in wound healing. It highlights recent advances in macrophage reprogramming, which facilitates the shift from pro-inflammatory to anti-inflammatory phenotypes, thereby promoting wound healing. Furthermore, the potential applications of biomaterials based on macrophage reprogramming mechanisms are discussed, emphasizing their role in regulating the wound microenvironment and enhancing the healing process. This review provides theoretical insights and practical guidance for improving the treatment of diabetic wounds.
