Biological significance of glucose metabolism in keloids
10.3760/cma.j.cn114453-20231026-00135
- VernacularTitle:瘢痕疙瘩中糖代谢的生物学意义
- Author:
Jingjun HUANG
1
;
Sujie WANG
1
;
Shengyuan JIN
1
Author Information
1. 延边大学附属医院整形烧伤科，延吉 133000
- Publication Type:Journal Article
- Keywords:
Keloid;
Glucose metabolism;
Warburg effect;
Inflammation;
Glucose transporter;
Lactate dehydrogenase;
Pyruvate kinase
- From:
Chinese Journal of Plastic Surgery
2024;40(12):1368-1372
- CountryChina
- Language:Chinese
-
Abstract:
Keloids are often accompanied by clinical manifestations such as itching, pain, and discomfort. Their biological characteristics bear similar to those of tumors, making keloids difficult to cure and prone to relapse. Recent research has identified a crucial role for alterations in cellular glucose metabolism in the pathogenesis of keloids. This paper summarized the research progress on cell glucose metabolism in keloids, explaining the tumor-like proliferation of keloid fibroblasts through aerobic glycolytic metabolism. Furthermore, it explored the influence of the relationship between endothelial cell and immune cell metabolism and inflammatory response on keloids. The roles of glucose transporter, lactate dehydrogenase, and pyruvate kinase in keloid were summarized here, providing more insights for the prevention and treatment of keloids.
