Correlation of GSDMD N-terminal domain with short-and long-term prognosis in patients with acute ischemic stroke
10.3969/j.issn.1009-0126.2024.12.016
- VernacularTitle:消皮素D蛋白N端结构域与急性缺血性脑卒中患者短期和长期预后的相关性研究
- Author:
Xiaohui LI
1
;
Xufeng CHEN
;
Li JI
;
Xuan WANG
;
Lina MAO
;
Yao WANG
;
Lili JIANG
;
Lei JIANG
Author Information
1. 210029 南京医科大学第一附属医院急诊与危重症医学科
- Publication Type:Journal Article
- Keywords:
stroke;
gasdermins;
prognosis;
forecasting;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(12):1457-1462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic effect of N-terminal domain of gasdermin-D(GSDMD-N)on the short-and long-term outcomes of patients with large-vessel occlusion(LVO)ischemic stroke.Methods A retrospective study was conducted on 65 patients with acute LVO is-chemic stroke admitted to Emergency Medicine Center of the First Affiliated Hospital of Nanjing Medical University from January to April 2023.According to their NIHSS score at and 5 d after admission,they were divided into a good prognosis group 1(34 cases)and a poor prognosis group 1(31 cases),and based on their mRS score at 90 d,they were also assigned into a good prognosis group 2(47 cases)and a poor prognosis group 2(18 cases).Their baseline data were collected,and univariate and multivariate regression analyses were performed to identify potential risk factors affecting short-term and long-term prognosis.GSDMD-N level was measured at and 24 h after ad-mission.ROC curves were plotted to analyze the predictive performance of GSDMD-N for poor prognosis.Results There were no significant differences between the good prognosis group 1 and the poor prognosis group 1 in terms of age,male,perfusion defect volume,time from onset to ad-mission,NIHSS score at admission,levels of GSDMD-N,S100β or syntaxin 17(STX17),hemor-rhagic complications,or ratios of intravenous thrombolysis,endovascular therapy,hypertension,diabetes,coronary heart disease,previous stroke,or atrial fibrillation(P＞0.05).Univariate and multivariate logistic regression analyses revealed that change in GSDMD-N from admission to 24 h later was an important factor influencing short-term poor prognosis(OR=1.054,95％CI:1.023-1.093,P=0.001;OR=1.072,95％CI:1.032-1.124,P=0.001).ROC curve analysis showed that change of GSDMD-N had good predictive value for short-term poor prognosis,with an AUC value of 0.814(95％CI:0.698-0.905).No statistical differences were observed between the good prog-nosis group 2 and poor prognosis group 2 in above indicators as between the good prognosis group 1 and poor prognosis group 1(P＞0.05).Univariate and multivariate logistic regression analyses revealed that change of GSDMD-N from admission to 24 h later was an important influencing fac-tor for long-term poor prognosis(OR=1.001,95％CI:1.023-1.069,P=0.046;OR=1.063,95％CI:1.017-1.125,P=0.015).ROC curve analysis displayed that the change also showed good pre-dictive value for long-term poor prognosis,with an AUC value of 0.881(95％CI:0.767-0.961).Conclusion Change in GSDMD-N from admission to 24 h later can predict the short-and long-term prognosis of patients with LVO ischemic stroke.
