Successful treatment of extracorporeal membrane oxygenation bridging to lung transplantation in a patient with rapidly progressive interstitial lung disease
10.12025/j.issn.1008-6358.2025.20251277
- VernacularTitle:体外膜肺氧合桥接肺移植成功救治快速进展性间质性肺病1例报告
- Author:
Yi GONG
1
;
Xinyu LING
2
;
Rui YAN
3
;
Bo SUN
4
;
Ke MA
4
;
Guifang WANG
1
;
Chang CHEN
2
Author Information
1. Department of Respiratory and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;Department of Respiratory and Critical Care Medicine, Quzhou Central Hospital, Quzhou 324000, Zhejiang, China.
2. Department of Thoracic Surgery, Pulmonary Hospital Affiliated to Tongji University, Shanghai 200070, China.
3. Department of Respiratory and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
4. Department of Critical Care Medicine, Huashan Hospital (Baoshan District), Fudan University, Shanghai 201900, China.
- Publication Type:Clinicalcaseanalysis
- Keywords:
extracorporeal membrane oxygenation;
rapidly progressive interstitial lung disease;
fibrotic nonspecific interstitial pneumonia;
lung transplantation;
bridging therapy
- From:
Chinese Journal of Clinical Medicine
2026;33(1):154-159
- CountryChina
- Language:Chinese
-
Abstract:
A 42-year-old male with chest tightness and dyspnea was admitted to the hospital. Chest CT indicated diffuse interstitial lung infiltration. Despite receiving anti-infective therapy, glucocorticoid therapy, and immunosuppressive agents, the patient developed refractory hypoxaemia. Endotracheal intubation and invasive mechanical ventilation failed to improve oxygenation. Therefore the patient was diagnosed with rapidly progressive interstitial lung disease (RP-ILD) accompanied by type Ⅰ respiratory failure. Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) was initiated, and oxygenation improved in this patient. The patient subsequently underwent bilateral lung transplantation with veno-arterio-venous (VAV) ECMO support. ECMO machine was withdrawn on day 1, and extubation was achieved on day 9 after surgery. Histopathology revealed fibrotic nonspecific interstitial pneumonia (NSIP) with hyaline membrane formation. The patient developed ICU-acquired myasthenia and received early rehabilitation, with gradual recovery of muscle strength. During follow-up, graft lung function remained stable. This case demonstrates that ECMO can serve as a bridge to lung transplantation in RP-ILD patients.
