Research progress on the relationship between brown adipose tissue and weight loss therapy
10.12025/j.issn.1008-6358.2025.20250226
- VernacularTitle:棕色脂肪组织在减重治疗中作用的研究进展
- Author:
Jiaojiao LIU
1
;
Zhitian ZHANG
1
;
Yin CHEN
1
;
Xijia HE
1
;
Hongmei YAN
1
;
Ruwen WANG
2
Author Information
1. Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2. School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
- Publication Type:Review
- Keywords:
brown adipose tissue;
obesity;
weight loss therapy;
clinical study;
animal study
- From:
Chinese Journal of Clinical Medicine
2026;33(1):113-120
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the rising prevalence of obesity and its associated metabolic syndromes has emerged as a critical global public health concern. Sustained weight loss exceeding 10% of total body weight has been shown to ameliorate obesity-related comorbidities, including type 2 diabetes mellitus, hypertension, and hepatic steatosis. Recently, the potential of brown adipose tissue (BAT) to improve metabolism has garnered significant attention. However, evidence regarding weight loss therapies that promote BAT activation remains limited in preclinical models and is even scarcer in clinical studies, partly due to the paucity of appropriate BAT assessment techniques. This review aims to explore the potential impact of various weight loss therapies on BAT, with the goal of providing novel insights and strategies for the treatment of obesity.
