Efficacy of integrated traditional Chinese and Western medicine in diabetic macular edema
10.12025/j.issn.1008-6358.2025.20250100
- VernacularTitle:中西医结合治疗糖尿病性黄斑水肿的效果
- Author:
Wei XU
1
;
Yinghua JIANG
2
;
Shusheng ZHANG
3
;
Jingjing LI
2
;
Yiyi CHEN
2
Author Information
1. Department of Optometry, Shanghai Eye Diseases Prevention & Treatment Center (Shanghai Eye Hospital, School of Medicine, Tongji University), Shanghai 200040, China;Department of Ophthalmology, Tongji Hospital of Tongji University, Shanghai 200065, China.
2. Department of Ophthalmology, Shanghai Nanxiang Hospital, Jiading District, Shanghai 201802, China.
3. Department of Otolaryngology, Shanghai Nanxiang Hospital, Jiading District, Shanghai 201802, China.
- Publication Type:Shortarticle
- Keywords:
diabetic macular edema;
anti-vascular endothelial growth factor;
replenishing qi and nourishing yin empirical formula;
best corrected visual acuity;
central macular thickness
- From:
Chinese Journal of Clinical Medicine
2026;33(1):102-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of combining the replenishing qi and nourishing yin empirical formula with anti-vascular endothelial growth factor (VEGF) in diabetic macular edema (DME). Methods A retrospective analysis was conducted on 59 patients diagnosed with DME at Tongji Hospital of Tongji University or Shanghai Nanxiang Hospital, Jiading District from June 2019 to December 2022. Among them, 29 cases received intravitreal injection of ranibizumab (anti-VEGF group), while 30 cases received both intravitreal injection of ranibizumab and oral administration of the replenishing qi and nourishing yin empirical formula (combined treatment group). The best corrected visual acuity (BCVA), central macular thickness (CMT), and the traditional Chinese medicine (TCM) syndrome score were compared between the two groups before treatment and at 4, 8, 12, 16, 20, and 24 weeks after treatment. Results Compared with before treatment, BCVA significantly improved (P＜0.05) and CMT significantly decreased (P＜0.05) at different time points after treatment in both groups. At 16, 20, and 24 weeks after treatment, BCVA in the combined treatment group was superior to that in the anti-VEGF group (P＜0.01). At 12, 16, 20, and 24 weeks after treatment, CMT in the combined treatment group was lower than that in the anti-VEGF group (P＜0.01). Starting from week 8 after treatment, the TCM syndrome scores in the combined treatment group were lower than those in the anti-VEGF group (P＜0.01). Conclusions The replenishing qi and nourishing yin empirical formula could improve the efficacy of anti-VEGF therapy in DME patients, indicating that integrating traditional Chinese and Western medicine has certain clinical application value in treating DME.
