Correlations between coronary stenosis severity and cardiac function and exercise tolerance
10.12025/j.issn.1008-6358.2025.20250861
- VernacularTitle:冠状动脉狭窄程度与心功能及运动耐力的相关性
- Author:
Xingguo ZHU
1
;
Zhenglong XIAO
1
;
Lei ZHUANG
2
;
Liangchen MA
3
;
Shouling MI
1
Author Information
1. Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, National Health Commission Key Laboratory of Ischemic Heart Diseases, National Clinical Research Center for Interventional Medicine, Shanghai 200032, China.
2. Department of Nursing, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
3. Department of Cardiology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, Henan, China.
- Publication Type:Shortarticle
- Keywords:
coronary artery stenosis;
Gensini score;
6-minute walk test;
left ventricular ejection fraction
- From:
Chinese Journal of Clinical Medicine
2026;33(1):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations of the severity degrees of coronary stenosis with cardiac function and exercise tolerance. Methods A total of 112 patients who underwent coronary angiography in Cardiology Department of Zhongshan Hospital, Fudan University between October 2024 and January 2025 were enrolled. According to the imaging results, the Gensini score was calculated, and the patients were divided into three groups based on the scores: mild group (＜20 points, n＝42), moderate group (20-40 points, n＝43), and severe group (＞40 points, n＝27). The left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP) level and its abnormal elevation ratio, 6-minute walk distance (6MWD), and grip strength were compared among the groups. The correlations between Gensini score and various indicators were analyzed using multivariate linear regression. And the multivariate binary logistic regression analysis was used to analyze the related factors of severe coronary stenosis. Results The 6MWD and LVEF values in the severe group were lower than those in the mild and moderate groups (P＜0.01), while the NT-proBNP level and its abnormal elevation ratio in the severe group were higher than those in the mild group (P＜0.05). The Gensini score was negatively correlated with 6MWD (β＝−0.965, P＜0.01), and positively correlated with NT-proBNP level and its abnormal elevation ratio (β＝0.015, P＜0.001; β＝0.003, P＝0.037). 6MWD and diabetes were independent related factors of severe coronary stenosis (OR＝0.956, P＜0.001; OR＝5.701, P＝0.038). Conclusions The cardiac function and exercise tolerance in patients with severe coronary stenosis decrease, 6MWD is helpful of recognizing severe coronary stenosis population.
