Values of non-invasive myocardial work and tissue motion annular displacement in evaluating anthracycline-induced cardiotoxicity
10.12025/j.issn.1008-6358.2025.20250378
- VernacularTitle:无创心肌做功及组织运动瓣环位移评估蒽环类药物心脏毒性的价值
- Author:
Wei HE
1
;
Hong WEI
1
;
Xiuli SUN
2
;
Ying LIU
3
;
Tao CONG
1
;
Yunlong XIA
4
Author Information
1. Department of Cardiovascular Ultrasound, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, Liaoning, China.
2. Department of Hematology , The First Affiliated Hospital of Dalian Medical University, Dalian 116021, Liaoning, China.
3. Department of Heart Failure and Hypertension, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, Liaoning, China.
4. Department of Arrhythmia, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, Liaoning, China.
- Publication Type:Shortarticle
- Keywords:
tissue motion annular displacement;
non-invasive myocardial work;
anthracycline;
cardiotoxicity
- From:
Chinese Journal of Clinical Medicine
2026;33(1):74-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical values of non-invasive myocardial work (MW) and tissue motion annular displacement (TMAD) in evaluation of anthracycline therapy-related cardiac dysfunction in patients with non-Hodgkin lymphoma. Methods A total of 62 patients with non-Hodgkin lymphoma who received standardized chemotherapy based on doxorubicin. Two and three dimensional transthoracic echocardiography, along with two dimensional speckle tracking echocardiography, were performed one day before chemotherapy and at 3, 6, and 9 months after chemotherapy to assess left ventricular ejection fraction, global longitudinal strain (GLS), MW parameters, and TMAD. Logistic regression analysis was used to evaluate the risk factors for cancer therapy-related cardiac dysfunction (CTRCD). The receiver operating characteristic curve was used to assess the diagnostic values of MW- and TMAD-related parameters for CTRCD. Results Compared to baseline, GLS, global work index (GWI), global constructive work (GCW), global work efficiency (GWE), TMAD at midpoint (TMADmid), and TMADmid percentage of left ventricular long-axis diameter (TMADmid%) decreased at 3 months after chemotherapy, while global wasted work (GWW) increased at 6 months after chemotherapy (P＜0.05). Logistic regression analysis showed that the relative reduction in GLS and TMADmid% at 3 months after chemotherapy were independent predictors for CTRCD （P＜0.05), while MW parameters were not independent predictors for CTRCD. GLS reduction≥10.3% and TMADmid% reduction≥15.8% at 3 months after chemotherapy predicted CTRCD with 0.866 and 0.824 of area under the curve (AUC), 92% and 75% of sensitivity, and 74% and 80% of specificity, respectively. AUC of combination of two indexes improved to 0.905, with 75% of sensitivity and 90% of specificity. Conclusions In non-Hodgkin lymphoma patients, the combination of GLS and TMADmid% is helpful of predicting CTRCD early, TMAD may be a novel diagnostic index for CTRCD, and GLS has superior predictive performance than MW for CTRCD.
