Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
10.12025/j.issn.1008-6358.2025.20251007
- VernacularTitle:中药防治抗肿瘤治疗相关药物性心肌损伤的研究进展
- Author:
Yanan GU
1
;
Guoping LI
1
;
Wei ZHANG
1
;
Dingfang CAI
2
;
Xiaolin WANG
1
Author Information
1. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Shanghai Institute of Medical Imaging, Shanghai 200032, China.
2. Department of Integrated Traditional Chinese and Western Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
Chinese traditional medicine;
anti-tumor therapy;
drug-induced myocardial injury;
cardioprotection
- From:
Chinese Journal of Clinical Medicine
2026;33(2):330-338
- CountryChina
- Language:Chinese
-
Abstract:
With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly impact patients’ quality of life and may even limit the overall efficacy of anti-tumor therapy. The underlying mechanisms include oxidative stress, inflammatory responses, mitochondrial dysfunction, apoptosis, and immune dysregulation. Owing to multitarget effects, low toxicity, and holistic regulatory properties, Chinese traditional medicines have demonstrated considerable potential in cardioprotection. This review summarizes the principal mechanisms of drug-induced myocardial injury related to anti-tumor therapy and highlights recent advances in the prevention and treatment of cardiotoxicity using Chinese medical formulae, such as compound danshen dripping pills, nuanxinkang, qili qiangxin capsules, and shengmai powder, as well as their bioactive constituents. The cardioprotective effects of these agents are discussed in terms of their antioxidative, anti-inflammatory, immunomodulatory, and mitochondrial-protective actions. Furthermore, it highlights certain traditional medicines that exhibit unique advantages in synergistic cardioprotective and anti-tumor therapy. Future efforts should focus on well-designed, systematic clinical studies to facilitate the translational application of integrated Chinese and Western medicine in cardio-oncology.
