Research advances in pathological mechanisms of coronary artery ectasia
10.12025/j.issn.1008-6358.2026.20251571
- VernacularTitle:冠状动脉扩张症的病理机制研究进展
- Author:
Min CHEN
1
;
Wei WEI
1
Author Information
1. Department of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
- Publication Type:Review
- Keywords:
coronary artery ectasia;
coronary artery aneurysm;
lipid metabolism;
inflammation;
matrix metalloproteinases;
clinical management
- From:
Chinese Journal of Clinical Medicine
2026;33(2):306-312
- CountryChina
- Language:Chinese
-
Abstract:
Coronary artery ectasia (CAE) is a vascular lesion characterized by abnormal dilation of the coronary arteries, with complex pathogenesis and diverse clinical manifestations. CAE can be classified into primary and secondary types. This article aims to systematically review the epidemiology, definition, core pathophysiological mechanisms, and clinical management strategies of primary CAE. It focuses on exploring the central roles and interactions of lipid metabolism disorders and chronic immune-inflammatory responses in the development and progression of the disease. Additionally, current therapeutic challenges and future research directions are discussed, with the goal of providing reference for clinical practice and basic research.
