Change in the number of peripheral blood regulatory T cells in patients with chronic kidney disease and its correlation with vascular calcification
10.12025/j.issn.1008-6358.2026.20251332
- VernacularTitle:慢性肾脏病患者外周血调节性T细胞数量变化及其与血管钙化的相关性
- Author:
Di ZHANG
1
;
Hui WU
2
;
Jing CHEN
1
;
Liyu LIN
3
;
Shaomin GONG
1
;
Xiaoyan ZHANG
1
;
Xiaoqiang DING
1
;
Han ZHANG
1
Author Information
1. Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2. Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
3. Department of Nephrology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, Fujian, China.
- Publication Type:Originalarticle
- Keywords:
chronic kidney disease;
vascular calcification;
regulatory T cell;
cytokine
- From:
Chinese Journal of Clinical Medicine
2026;33(2):285-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the number of peripheral blood regulatory T cells (Treg) in patients with chronic kidney disease (CKD) and its correlation with vascular calcification. Methods This was a single-center, cross-sectional, and observational study. Non-dialysis patients with CKD treated at Zhongshan Hospital, Fudan University from March 2021 to March 2022 were enrolled. Abdominal aortic calcification (AAC) was assessed using lateral abdominal X-ray. Number of Treg and cytokine levels were measured by flow cytometry. Logistic regression analysis was performed to evaluate the related factors for AAC in CKD patients. Results A total of 83 patients were included, aged 17–86 years, with 57 males (68.7%). The distribution of CKD stages was as follows: stage G1 in 7 patients (8.4%), stage G2 in 17 patients (20.5%), stage G3 in 21 patients (25.3%), stage G4 in 19 patients (22.9%), and stage G5 in 19 patients (22.9%). No AAC was observed in patients with stages G1 and G2, while the prevalence of AAC in patients with stages G3, G4, and G5 was 23.8%, 21.1%, and 26.3%, respectively. Compared with stage G1 patients, those with stages G3–5 showed decreased number of peripheral blood Treg and elevated levels of interleukin (IL)-6 and IL-17F (P＜0.05). The area under the receiver operating characteristic curve for number of peripheral blood Treg in predicting AAC in CKD patients was 0.766 (95%CI 0.652–0.879, P＝0.002). Logistic regression analysis showed that decreased number of Treg was related factor for AAC in CKD patients (OR＝0.957, 95%CI 0.922–0.992, P＝0.018). Conclusion As CKD progresses, number of peripheral blood Treg significantly decreases, which is correlated with AAC in CKD patients.
