Research progress on the intervention of sarcopenia with traditional Chinese medicine based on the AMPK signaling pathway
- VernacularTitle:基于AMPK信号通路探讨中药干预肌少症的研究进展
- Author:
Wenyu FAN
1
;
Bairong HUANG
2
;
Congmin HONG
2
;
Yan CHEN
1
;
Jiayin WANG
1
;
Jing GAO
3
;
Xiaodong FENG
3
Author Information
1. School of Rehabilitation Sciences，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Clinical Medical College of Acupuncture Moxibustion and Rehabilitation，Guangzhou University of Chinese Medicine，Guangzhou 510006，China
3. Rehabilitation Diagnosis and Treatment Center，the First Affiliated Hospital，Henan University of Traditional Chinese Medicine，Zhengzhou 450099，China
- Publication Type:Journal Article
- Keywords:
sarcopenia;
AMPK;
traditional Chinese medicine monomer;
traditional Chinese medicine extract;
traditional
- From:
China Pharmacy
2026;37(9):1229-1235
- CountryChina
- Language:Chinese
-
Abstract:
arcopenia is a systemic skeletal muscle disorder characterized by a decrease in skeletal muscle mass and progressive decline in function， with multiple signaling pathways involved in its occurrence and development. Among them， the AMP-activated protein kinase （AMPK） signaling pathway， as a key pathway regulating cellular energy homeostasis， plays an important role in the regulation of skeletal muscle metabolism and functional maintenance by improving abnormalities in glucose and lipid metabolism， balancing skeletal muscle protein synthesis and degradation， improving mitochondrial function， promoting autophagy， and inhibiting inflammatory responses and oxidative stress. This article reviews the research progress on how various traditional Chinese medicine （TCM） monomers， including polyphenols， flavonoids， and terpenoids； various traditional Chinese medicine extracts， such as those from Lycium barbarum ， Asini Corii Colla， and Panax quinquefolium ， and TCM compounds， such as Guiqi zhuangjin decoction， Jianpi qiangji granules， and Qigu capsules， intervene in sarcopenia by regulating the AMPK signaling pathway to promote muscle protein synthesis， inhibit protein degradation， improve mitochondrial function， and alleviate inflammation and oxidative stress. Additionally， their molecular mechanisms are explored. The aim is to deeply elucidate the basis of TCM in the prevention and treatment of sarcopenia and to provide theoretical support for the development of related innovative drugs.
