Non-correction in APTT correction test due to high-titer FⅧ inhibitors: a case report and literature review
10.13303/j.cjbt.issn.1004-549x.2026.04.020
- VernacularTitle:高滴度FⅧ抑制物致APTT纠正试验不可纠正1例并文献复习
- Author:
Jia LIU
1
;
Na WANG
1
Author Information
1. Department of Blood Transfusion, the Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai 264200, China
- Publication Type:Journal Article
- Keywords:
prolonged APTT;
APTT correction test;
high-titer FⅧ inhibitors
- From:
Chinese Journal of Blood Transfusion
2026;39(4):552-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the causes of patients with large-area bruising and hematoma on the left chest wall after fracture accompanied by significantly prolonged activated partial thromboplastin time (APTT), clarify the interference mechanism of high-titer factor Ⅷ (FⅧ) inhibitors on the APTT correction test, and provide references for clinicians to interpret test results and avoid misjudgment. Methods: A retrospective analysis was conducted on the clinical data of a patient with large-area bruising and hematoma on the left chest wall after fracture. Tests including APTT, prothrombin time (PT), fibrinogen (FIB), FⅧ activity, and inhibitor titers were completed. The results of the APTT correction test were analyzed, and the interference characteristics were discussed along with a literature review. Results: On admission, the patient's APTT was 94.0 s, while PT and FIB were normal; the Rosner indices for APTT immediately and after 2 hours incubation at 37℃ were 55.11 and 53.21, respectively; FⅧ activity was 0.64%, and the inhibitor titers were 3 379 BU·mL
, confirming that the high-titer FⅧ inhibitors caused a 'pseudo' failure to correct in the APTT correction test. Conclusion: High-titer FⅧ inhibitors can lead to a 'pseudo' failure to correct in the APTT correction test. Clinicians need to complete relevant tests in a timely manner and make a comprehensive judgment based on symptoms to avoid missed diagnoses and misdiagnosis.
