Overcoming organ shortage: key clinical application technology breakthroughs and future prospects in xenogeneic organ transplantation
10.12464/j.issn.1674-7445.2025295
- VernacularTitle:破局器官短缺：异种器官移植的关键临床应用技术突破与未来展望
- Author:
Junze CHEN
1
;
Cheng ZHANG
1
;
Yongyuan JIAN
1
;
Kun DONG
1
;
Shuaijun MA
2
;
Chunqiang DONG
1
Author Information
1. Department of Organ Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
2. null.
- Publication Type:TransplantationForefront
- Keywords:
Xenotransplantation;
Genetically modified pig;
Organ transplantation;
Clinical research;
Transformation;
Immunosuppression;
Rejection;
Gene-knockout
- From:
Organ Transplantation
2026;17(3):393-404
- CountryChina
- Language:Chinese
-
Abstract:
The technology of xenogeneic organ transplantation, as one of the core strategies to address the current contradiction between the supply and demand of transplant organs, has achieved significant breakthroughs from basic research to clinical application driven by factors such as the innovation of gene modification technology, the injection of research capital and the expansion of clinical trials, especially with the first actual clinical application of a pig heart-to-human transplant. China is also at the forefront of this field. This article intends to summarize the international research trends of xenogeneic organ transplantation (including financial support, the evolution of research stages and global clinical trial cases), and analyze the evolution and optimization of xenogeneic transplantation immunosuppression schemes, as well as the breakthroughs and unresolved scientific issues in current key clinical application technologies. The aim is to comprehensively present the progress of this field from basic research to clinical transformation, and provide references for promoting the rapid development of China's xenogeneic transplantation technology and subsequent clinical transformation and research directions.
