Efficacy and Economic Evaluation of Weishi Qingjin Formula （苇石清金方）in the Treatment of Adult Community-Acquired Pneumonia with Phlegm-Heat Obstructing the Lung Syndrome：A Multicenter Retrospective Real-World Cohort Study
10.13288/j.11-2166/r.2026.09.010
- VernacularTitle:苇石清金方治疗成人社区获得性肺炎痰热壅肺证的真实世界疗效及经济学评价——一项多中心回顾性队列研究
- Author:
Yeqing JI
1
;
Ye MA
1
;
Zhichao WANG
1
;
Fanchao FENG
1
;
Mingzhi PU
2
;
Hong LYU
3
;
Xiaodong HU
4
;
Gaohua FENG
5
;
Xiaoqian FANG
6
;
Guicai ZHANG
7
;
Yanfen TANG
8
;
Yeqing ZHANG
9
;
Yao ZHUFU
10
;
Wenpan PENG
2
;
Hao WANG
7
;
Cheng GU
10
;
Zhichao ZHANG
1
;
Shuang YANG
1
;
Xinyu SUN
1
;
Qi ZHAO
1
;
Aojie GUO
1
;
Xin TONG
11
;
Zhuoyue WU
11
;
Xiaoxiao WANG
1
;
Jia LIU
12
;
Hailang HE
1
;
Xianmei ZHOU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing，210029
2. Suzhou Affiliated Hospital of Traditional Chinese Medicine，Nanjing University of Chinese Medicine
3. Taicang Affiliated Hospital of Nanjing University of Chinese Medicine
4. Jiangyin Affiliated Hospital of Nanjing University of Chinese Medicine
5. Zhangjiagang Affiliated Hospital of Nanjing University of Chinese Medicine
6. Nanjing Integrated Traditional Chinese and Western Medicine Hospital，Nanjing University of Chinese Medicine
7. Yancheng Affiliated Hospital of Nanjing University of Chinese Medicine
8. Nantong Affiliated Hospital of Nanjing University of Chinese Medicine
9. Jiangsu Province Integrated Traditional Chinese and Western Medicine Hospital，Nanjing University of Chinese Medicine
10. The Second Affiliated Hospital of Nanjing University of Chinese Medicine
11. School of Public Health，Nanjing Medical University
12. Institute of Basic Research in clinical Medicine，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
community‑acquired pneumonia;
phlegm‑heat obstructing the lung syndrome;
real‑world study;
economic evaluation;
Weishi Qingjin Formula （苇石清金方）
- From:
Journal of Traditional Chinese Medicine
2026;67(9):975-984
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the real‑world effectiveness and economic outcomes of Weishi Qingjin Formula （苇石清金方， WQF） in the treatment of adult community‑acquired pneumonia （CAP） with phlegm‑heat obstructing the lung syndrome. MethodsBased on a multicenter， real-world retrospective cohort study， clinical data were collected from hospitalized adult patients diagnosed with non‑severe CAP and phlegm‑heat obstructing the lung syndrome in 10 traditional Chinese medicine （TCM） hospitals in Jiangsu province. Patients were divided into an exposure group （those who received oral WQF） and a non‑exposure group （those who did not）. The following outcomes were compared between the two groups before and after treatment， which were remission rates of clinical symptoms including cough， expectoration （sputum volume， color， consistency）， and chest pain， levels of inflammatory markers including C‑reactive protein （CRP） and white blood cell count （WBC）， and the rate of pulmonary inflammatory absorption on chest CT. Subgroup analyses were performed based on age， gender， smoking status， presence of hypertension， and the severity of community-acquired pneumonia （CURB‑65） score， comparing the two groups in terms of cough remission rate， chest pain remission rate， and chest CT absorption rate. For health economic evaluation， cost‑effectiveness analysis was used to calculate the cost‑effectiveness ratio （CER） and incremental cost‑effectiveness ratio （ICER）. Univariate sensitivity analysis and probabilistic sensitivity analysis were performed to test the robustness of the results. ResultsA total of 647 patients in the exposure group and 1491 patients in the non-exposure group were included in the final statistical analysis. There was no statistically significant difference in length of hospital stay， gender， marital status， smoking history， bronchoscopy history， and comorbidities between the groups （P＞0.05）， but age， CURB-65 score， and antibiotic use. The exposure group had significantly higher remission rates of cough and sputum consistency than the non-exposure group （P＜0.05）. After adjusting for confounders using propensity score matching and logistic regression， the cough remission rate in the exposure group was 1.49 times that of the non-exposure group （P＜0.01）. No significant difference was observed between groups in the reduction rates of CRP and WBC， and in the rate of pulmonary inflammatory absorption on chest CT （P＞0.05）. Subgroup analyses revealed that the cough remission rate in the exposure group was significantly better than that in the non-exposure group except for patients aged ≥65 years， smokers， hypertensive patients， those using other type antibiotics or not using antibiotics， and those with a CURB-65 score ≥1 （P＜0.05）. Among smokers， the chest pain remission rate in the exposure group was 4.38 times that of the non-exposure group （P＜0.01）. No significant difference in chest CT absorption rate was found between groups across subgroups of gender， age， hypertension status， or antibiotic type （P＞0.05）. In terms of economic evaluation， CER was 10,877.60 CNY/case in the exposure group and 16,773.10 CNY/case in the non-exposure group. Compared to the exposure group， the non-exposure group incurred an additional 15,034.26 CNY to achieve one case of cough resolution， indicating a more favorable cost-effectiveness profile. Probabilistic sensitivity analysis yielded results consistent with the cost-effectiveness analysis， confirming the robustness of the findings. ConclusionWQF demonstrates significant efficacy in improving cough symptoms in the treatment of adult CAP with phlegm-heat obstructing the lung syndrome， and also exhibits favorable economic benefits.
