Molecular mechanisms of hyperlipidemic acute pancreatitis comorbid with fatty liver disease
- VernacularTitle:高脂血症性急性胰腺炎合并脂肪性肝病的分子机制
- Author:
Shuo DONG
1
;
Ying WANG
1
;
Xiwang WANG
1
;
Jingjing JIN
1
;
Kai WEI
1
;
Xiao WANG
1
Author Information
- Publication Type:Review
- Keywords: Pancreatitis; Hyperlipidemias; Fatty Liver; Signaling Pathway
- From: Journal of Clinical Hepatology 2026;42(3):739-744
- CountryChina
- Language:Chinese
- Abstract: Both hyperlipidemic acute pancreatitis and fatty liver disease are associated with lipid metabolism disorders and are commonly comorbid with each other in clinical practice. The pathogenesis of such comorbidity involves the interaction between multiple factors such as hypertriglyceridemia， metabolic syndrome， obesity， and insulin resistance， and these factors may form a vicious cycle and jointly promote disease progression. In clinical practice， hyperlipidemic acute pancreatitis is characterized by severe disease conditions， a high incidence rate of complications， a high mortality rate， and a tendency for recurrence， and it can easily lead to multi-organ damage and even multiple organ failure without timely treatment， posing a serious threat to the life of patients. Starting from the various signaling pathways associated with hyperlipidemic acute pancreatitis comorbid with fatty liver disease， this article discusses the potential molecular mechanisms of synergistic pathogenesis between hyperlipidemic acute pancreatitis and fatty liver disease， so as to provide a reference for the early prevention and treatment of such comorbidity.
