Mechanism of ductular reaction and related treatment strategies

VernacularTitle:胆管反应的发生机制及治疗策略
Author: Jiayan SHAN ¹ ; Huaqian XU ² ; Chengzhi BAI ² ; Liang ZHANG ² ; Chao DU ² ; Yong ZHANG ² ; Shanhong TANG ¹
Author Information

1. School of Medical and Life Sciences， Chengdu University of Traditional Chinese Medicine， Chengdu 610075， China
2. Department of Gastroenterology， The General Hospital of Western Theater Command， Chengdu 610083， China
Publication Type:Review
Keywords: Bile Duct Diseases; Fibrosis; Therapeutics
From: Journal of Clinical Hepatology 2026;42(3):733-738
CountryChina
Language:Chinese
Abstract: Ductular reaction （DR） refers to the adaptive pathological changes that occur after hepatobiliary injury， and it is essentially a repair response involving the proliferation， fibrosis， and inflammation of biliary epithelial cell （BEC）. With the understanding of the biological function of BEC， the potential value of DR in disease prognosis and treatment has gradually become a research hotspot. This article systematically reviews the molecular mechanism of DR， its potential as a therapeutic target， and future development directions， as well as novel therapies suggested by targeting these molecular mechanisms， in order to provide a new direction for overcoming current bottlenecks in the treatment of bile duct diseases.