Novel pathogenesis and intervention strategies for liver cirrhosis based on the gut microbiota-bile acid axis
- VernacularTitle:基于肠道菌群-胆汁酸轴探讨肝硬化的发病新机制及干预策略
- Author:
Ningning LIU
1
;
Wenting CUI
1
;
Shuli MU
1
;
Xiuzhen MA
2
;
Ping MAI
2
Author Information
- Publication Type:Review
- Keywords: Liver Cirrhosis; Gastrointestinal Microbiome; Bile Acid
- From: Journal of Clinical Hepatology 2026;42(3):718-725
- CountryChina
- Language:Chinese
- Abstract: Liver cirrhosis is the final stage of the progression of various chronic liver diseases， often accompanied by serious complications and high mortality rates. Recent studies have shown that the interaction between gut microbiota and bile acid metabolism （the gut microbiota-bile acid axis） is closely associated with liver cirrhosis. This article systematically reviews the mechanism of action of the gut microbiota-bile acid axis in the progression of liver cirrhosis， elaborates on the pathological features of liver cirrhosis and its harm to the body， and summarizes the association of the gut microbiota-bile acid axis with the development and progression of liver cirrhosis. It also analyzes the key regulatory role of this axis in the progression of liver cirrhosis and explores its potential application value as a therapeutic target for liver cirrhosis， in order to provide a theoretical basis for exploring more effective clinical intervention methods.
