Regulatory effect of histone lactylation modification in hepatic fibrosis

Weichu ZENG; Xing LYU; Fengfan LI; Zhenni LIU; Jungang LI; Weilin ZHANG; Peiting LIU; Bingchu LI; Ruohong CHEN; Zhiyang CHEN; Min HU

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Regulatory effect of histone lactylation modification in hepatic fibrosis

VernacularTitle:组蛋白乳酸化修饰在肝纤维化中的调控作用
Author: Weichu ZENG ¹ ; Xing LYU ¹ ; Fengfan LI ¹ ; Zhenni LIU ¹ ; Jungang LI ¹ ; Weilin ZHANG ¹ ; Peiting LIU ¹ ; Bingchu LI ¹ ; Ruohong CHEN ¹ ; Zhiyang CHEN ¹ ; Min HU ¹
Author Information

1. Department of Laboratory Medicine， The Second Xiangya Hospital of Central South University， Hunan Clinical Molecular Diagnosis Center， Hunan Engineering Research Center of Molecular Diagnosis Technology， Hunan Clinical Medical Research Center of Molecular Diagnosis of Infectious Diseases， Changsha 410011， China
Publication Type:Review
Keywords: Histone Lactylation; Hepatic Fibrosis; Hepatic Stellate Cells
From: Journal of Clinical Hepatology 2026;42(3):704-710
CountryChina
Language:Chinese
Abstract: Hepatic fibrosis is a reversible pathological process in various chronic liver diseases and is closely associated with the development and progression of severe liver diseases such as liver cirrhosis and hepatocellular carcinoma， and it has emerged as a significant global health challenge. In recent years， studies have shown that histone lactylation， a newly discovered epigenetic modification， actively participates in regulating the progression of hepatic fibrosis. This article systematically reviews the core regulatory effect of histone lactylation modification in the interaction between inflammatory microenvironment and hepatic fibrosis， in order to clarify the cascade regulatory mechanism of “inflammation-hepatic fibrosis” and provide new insights for early diagnosis， targeted intervention， and prevention of malignant transformation in hepatic fibrosis.