Regulatory effect of ten-eleven translocation 2-mediated epigenetics and the interaction between gut microbiota and immunity on autoimmune hepatitis

VernacularTitle:10-11易位蛋白2（TET2）介导的表观遗传与肠道微生物-免疫互作对自身免疫性肝炎的调控作用
Author: Lifen WANG ¹ ; Ling LI ¹ ; Guangwei LIU ²
Author Information

1. Department of Spleen， Stomach， Liver and Gallbladder， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
2. Department of Hepatology， Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 200032， China
Publication Type:Review
Keywords: Hepatitis， Autoimmune; Epigenomics; Gastrointestinal Microbiome
From: Journal of Clinical Hepatology 2026;42(3):697-703
CountryChina
Language:Chinese
Abstract: Ten-eleven translocation 2 （TET2）， as a core enzyme in epigenetic regulation， dynamically regulates the differentiation and function of CD4⁺ T cells by mediating DNA demethylation. Recent studies have shown that TET2 deficiency can promote the progression of autoimmune hepatitis （AIH） by disrupting the Th17/Treg balance and activating inflammatory signals along the gut-liver axis. This article systematically reviews the bridging role of TET2 between CD4⁺ T cells and gut microbiota， explores the molecular mechanisms by which it drives AIH through the gut microbiota-epigenetics-immunity network， and discusses the potential intervention strategies targeting the TET2-microbiota axis.