Pathogenesis， clinical assessment， and intervention of fatigue in patients with primary biliary cholangitis
- VernacularTitle:原发性胆汁性胆管炎患者疲劳的发生机制及临床评估与干预
- Author:
Weirui REN
1
;
Chuang ZHANG
2
;
Wenjuan ZHAO
1
;
Junmin WANG
1
Author Information
- Publication Type:Review
- Keywords: Primary Biliary Cholangitis; Fatigue; Therapeutics
- From: Journal of Clinical Hepatology 2026;42(3):690-696
- CountryChina
- Language:Chinese
- Abstract: Primary biliary cholangitis （PBC） is an autoimmune liver disease characterized by intrahepatic cholestasis， while fatigue is a common symptom of PBC that significantly affects the quality of life of patients. The pathogenesis of fatigue is complex and may be associated with the factors such as cholestasis-induced inflammation， gut microbiota dysbiosis， brain structural and functional abnormalities， and mitochondrial dysfunction. At present， first-line therapies and liver transplantation have a limited effect in alleviating fatigue， and there is still a lack of standardized comprehensive assessment system. Emerging drugs and non-pharmaceutical interventions， including lifestyle modifications， have shown potential application prospects. This article systematically reviews the research advances in the clinical manifestations， pathogenesis， clinical assessment， and intervention of fatigue in PBC patients， in order to provide a reference for optimizing treatment strategies and promoting the research and development of new therapies.
