Regulatory role and mechanism of intrahepatic macrophages in metabolic dysfunction-associated fatty liver disease
- VernacularTitle:肝内巨噬细胞在代谢相关脂肪性肝病中的调控作用及其机制
- Author:
Chuanwang QI
1
;
Ying ZHU
1
Author Information
- Publication Type:Review
- Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Macrophages; Hepatic Stellate Cells
- From: Journal of Clinical Hepatology 2026;42(3):668-675
- CountryChina
- Language:Chinese
- Abstract: With the improvement of living standards， the incidence rate of metabolic dysfunction-associated fatty liver disease （MAFLD） is gradually increasing with a younger age of onset， and MAFLD has become a global health problem， while its specific pathogenesis remains unclear. Macrophages， as one of the important cells involved in the pathogenesis of MAFLD， have the ability to present antigens， eliminate pathogenic microorganisms， and promote liver inflammatory responses， thereby attracting wide attention for a long time. The latest studies have shown that macrophages may become a new therapeutic target for MAFLD. This article systematically reviews the role of intrahepatic macrophages in liver inflammation caused by MAFLD， including their activation， polarization， recruitment mechanisms， and interactions with other cells， in order to provide new ideas and perspectives for the clinical prevention and treatment of MAFLD.
